PRECISION (PREvent ductal Carcinoma In Situ Invasive Overtreatment Now)

When is cancer not really cancer? Distinguishing indolent from aggressive ductal carcinoma in situ (DCIS) in order to reduce overtreatment and life-long side effects.

While early cancer detection may offer a survival benefit, increasing numbers of ‘pre-cancerous lesions’ are also being identified that will never develop into lethal disease. These ‘pre-cancers’ are often treated aggressively to prevent potential progression into invasive cancer. This implies many pre-cancerous lesions are likely to be over treated.

Ductal carcinoma in situ (DCIS) is a prime example of potential overtreatment. DCIS is frequently detected by screening mammography, accounting for one quarter of all breast cancers diagnosed today. DCIS is usually treated similar to invasive breast cancer with surgery, radiation and hormone-blocking medicines. Despite newer research concluding these interventions provide no difference in survival, aggressive ‘cancer’ treatments remain the “standard of care,” and many women world-wide are faced with the life-long emotional, physical and financial consequences of aggressive treatments. Understanding how DCIS evolves and developing markers for which DCIS may or may not progress to invasive breast cancer, are pressing needs for the tens of thousands of women diagnosed with DCIS each year.

PRECISION is an international collaboration building on multiple studies conducted in the UK, Europe, and the US over the last two decades. PRECISION aims to establish tests to reduce the burden of unnecessary surgery, radiation and hormone-blocking therapies used in managing DCIS, reducing overtreatment without compromising the excellent outcomes for DCIS presently achieved.

PRECISION will use a range of established and innovative laboratory methods applied to DCIS pathology sample collections to identify and validate features distinguishing aggressive from harmless DCIS.

The Patient Involvement Panel is involved in the whole project lifecycle.

Project lead

Dr Jelle Wesseling

Senior Group Leader & Consultant Breast Pathologist

The Netherlands Cancer Institute,

Amsterdam, The Netherlands

Overview of the project

Overview of the projcect

PRECISION: from DCIS lesion to clinical test to make a difference between indolent and aggressive DCIS

Partners

AVL
MD Anderson
University of Birmingham
Cancer Research UK
Borstkankervereniging Nederland
Voice
Cambridge
Patient advocates in research
KWF
DCIS 411
Kings

PRECISION kick off meeting in Amsterdam

Steering group, collaborators and all patient advocates came together to celebrate the start of PRECISION. Research plans were discussed as well as the collaboration in more detail.

Film: KWF Challenge Jelle Wesseling