Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast

Maartje van Seijen, Esther H. Lips , Liping Fu, Daniele Giardiello, Frederieke van Duijnhoven, Linda de Munck , Lotte E. Elshof, Alastair Thompson, Elinor Sawyer , Marc D. Ryser, E. Shelley Hwang, Marjanka K. Schmidt, Paula H. M. Elkhuizen, Grand Challenge PRECISION Consortium, Jelle Wesseling and Michael Schaapveld
Br J Cancer (2021); Aug 18


Treating (low-risk) DCIS patients: What can we learn from real-world cancer registry evidence?

Byng D, Retèl VP, Schaapveld M, Wesseling J, van Harten WH; Grand Challenge PRECISION consortium.
Breast Cancer Res Treat. 2021 May;187(1):187-196.


Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ

Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser , Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi , Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg , Wilbert Zwart, Esther H. Lips , Grand Challenge PRECISION Consortium*, Christine Desmedt and Jelle Wesseling
npj Breast Cancer (2021) 7:31, March 22
Plain Language Summary (English): Click here
Plain Language Summary (Spanish): Click here
News: Could the size of fat cells around DCIS breast lesions predict risk of future invasive cancer? | Cancer Grand Challenges
News: How fat cells could help predict breast cancer | Netherlands Cancer Institute (
Blog: Predicting future breast cancer with precision – Cancer Research UK – Science blog


Variability in grading of ductal carcinoma in situ among an international group of pathologists

Maartje van Seijen, Katarzyna Józ´ wiak, Sarah E Pinder, Allison Hall, Savitri Krishnamurthy, Jeremy SJ Thomas, Laura C Collins, Jonathan Bijron, Joost Bart, Danielle Cohen, Wen Ng, Ihssane Bouybayoune, Hilary Stobart, Jan Hudecek, Michael Schaapveld, Alastair Thompson, Esther H Lips, and Jelle Wesseling * on behalf of the Grand Challenge PRECISION consortium.
J Pathol Clin Res 2021 Feb 23
doi: 10.1002/cjp2.201 (
Plain Language Summary (English): Click here
Plain Language Summary (Spanish): Click here


Contralateral breast cancer risk in patients with ductal carcinoma in situ and invasive breast cancer

Daniele Giardiello, Iris Kramer, Maartje J. Hooning, Michael Hauptmann, Esther H. Lips, Elinor Sawyer, Alastair M. Thompson, Linda de Munck, Sabine Siesling, Jelle Wesseling, Ewout W. Steyerberg and Marjanka K. Schmidt
npj Breast Cancer 6, 60 (2020).
Plain Language Summary (English): Click here
Plain Language Summary (Spanish): Click here
Oncologieuptodate: Click Here


Prognostic value of histopathological DCIS features in a large scale international interrater reliability study

EmmaJ.Groen, Jan Hudecek, Lennart Mulder, Maartje van Seijen, Mathilde M.Almekinders, Stoyan Alexov, Anikó Kovács, Ales Ryska, Zsuzsanna Varga, Francisco Javier Andreu Navarro, Simonetta Bianchi, Willem Vreuls, Eva Balslev, Max V.Boot, Janina Kulka, Ewa Chmielik, Ellis Barbé, Mathilda Rooij, Winand Vos, Andrea Farkas, Natalja E.Leeuwis Fedorovich, Peter Regitnig, Pieter J.Westenend, Loes F.S.Kooreman, Cecily Quinn, Giuseppe Floris, Gábor Cserni, Paul J.van Diest, EstherH.Lips, Michael Schaapveld, Jelle Wesseling on behalf of Grand Challenge PRECISION consortium
Breast Cancer Research and Treatment
Published online 30th July 2020


PRECISION Newsletter Volume 2, Issue 1, July 2020


The impact of patient characteristics and lifestyle factors on the risk of an ipsilateral event after a primary DCIS: A systematic review

Sena Alaeikhanehshir, Ellen G. Engelhardt, Frederieke H. van Duijnhoven, Maartje van Seijen, Patrick A. Bhairosing, Donna Pinto, Deborah Collyar, Elinor Sawyer, Shelley E. Hwang, Alastair M. Thompson, Jelle Wesseling, Esther H. Lips, Marjanka K. Schmidt on behalf of PRECISION
Breast 2020 Apr; 50: 95–103.
doi: 10.1016/j.breast.2020.02.006
Plain Language Summary (English): Click here
Plain Language Summary (Spanish): Click here


Calcification Microstructure Reflects Breast Tissue Microenvironment

Sarah Gosling, Robert Scott, Charlene Greenwood, Pascaline Bouzy, Jayakrupakar Nallala, Iain D. Lyburn, Nicholas Stone, Keith Rogers
Journal of Mammary Gland Biology and Neoplasia volume 24, pages333–342(2019)


Ductal carcinoma in situ: to treat or not to treat, that is the question

Maartje van Seijen, Esther H. Lips, Alastair M. Thompson, Serena Nik-Zainal, Andrew Futreal, E. Shelley Hwang, Ellen Verschuur, Joanna Lane, Jos Jonkers, Daniel W. Rea and Jelle Wesseling on behalf of the PRECISION team
British Journal of Cancer volume 121, pages285–292(2019)


PRECISION Newsletter Volume 1, Issue 1, June 2019


Prediction of Upstaged Ductal Carcinoma in situ Using Forced Labeling and Domain Adaptation 

Rui Hou, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E. Shelley Hwang, and Joseph Y. Lo
IEEE Transactions on Biomedical Engineering (Early Access)
doi: 10.1109/TBME.2019.2940195


Predictors of an Invasive Breast Cancer Recurrence after DCIS: A Systematic Review and Meta-analyses 

Lindy L. Visser, Emma J. Groen, Flora E. van Leeuwen, Esther H. Lips, Marjanka K. Schmidt, and Jelle Wesseling
Cancer Epidemiology, Biomarkers and Prevention
doi: 1055-9965.EPI-18-0976