Publications

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts

Hutten S.J., Messal, H.A., Lips, E.H., Sheinman, M., Ciwinska,M., Braams, E., van der Borden, C., Kristel, P.,Stoffers, S., Wessels, L.F.A., Grand Challenge PRECISION Consortium, Jonkers,J., van Rheenen,J., Wesseling,J., Scheele, C.L.G.J. J Pathol 2024 Published online 23 May 2024.
doi: https://doi.org/10.1002/path.6289

Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study.

R.S.J.M. Schmitz, A.W. van den Belt-Dusebout, K. Clements, Y. Ren, C. Cresta, J. Timbres, Y. Liu, D. Byng, T. Lynch, B.A. Menegaz, D. Collyar, T. Hyslop , S. Thomas, J.K. Love, M. Schaapveld, P. Bhattacharjee, M.D. Ryser, E. Sawyer, E.S. Hwang, A. Thompson, J. Wesseling, E.H. Lips, M.K. Schmidt, professor, Grand Challenge PRECISION. British Medical Journal, 2023  Oct 30:383:e076022
doi: https://doi.org/10.1136/bmj-2023-076022
News: https://cancergrandchallenges.org/news/changing-narrative-around-ductal-carcinoma-situ-and-breast-cancer-risk

Archival single-cell genomics reveals persistent subclones during DCIS progression.

Wang K, Kumar T, Wang J, Minussi DC, Sei E, Li J, Tran TM, Thennavan A, Hu M, Casasent AK, Xiao Z, Bai S, Yang L, King LM, Shah V, Kristel P, van der Borden CL, Marks JR, Zhao Y, Zurita AJ, Aparicio A, Chapin B, Ye J, Zhang J, Gibbons DL; Grand Challenge PRECISION Consortium; Sawyer E, Thompson AM, Futreal A, Hwang ES, Wesseling J, Lips EH, Navin NE. Cell. 2023 Aug 31; 186(18):3968-3982.e15.
doi: https://doi.org/10.1016/j.cell.2023.07.024

Active surveillance versus treatment in low-risk DCIS: Women’s preferences in the LORD-trial.

Renée S J M Schmitz, Ellen G Engelhardt, Miranda A Gerritsma, Carine M T Sondermeijer, Ellen Verschuur, Julia Houtzager, Rosalie Griffioen, Valesca Retèl, Nina Bijker , Ritse M Mann, Frederieke van Duijnhoven , Jelle Wesseling , Eveline M A Bleiker ; Grand Challenge PRECISION Consortium. Eur. J. Canc. 2023. Oct: 192:113276.
doi: https://doi.org/10.1016/j.ejca.2023.113276

Surveillance Imaging after Primary Diagnosis of Ductal Carcinoma in Situ.

Danalyn Byng, Samantha M. Thomas, Christel N. Rushing, Thomas Lynch, Anne McCarthy, Amanda B. Francescatti, Elizabeth S. Frank, Ann H. Partridge, Alastair M. Thompson, Valesca P. Retèl, Wim H. van Harten, Lars J. Grimm, Terry Hyslop, E. Shelley Hwang, Marc D. Ryser. Radiology 2023.
doi: https://doi.org/10.1148/radiol.221210

Human Ductal Carcinoma In Situ: Advances and Future Perspectives.

Fariba Behbod, Jennifer H Chen and Alastair Thompson. Cold Spring Harb Perspect Med 2023 Oct 3;13(10):a041319.Online ahead of print.
doi: https://doi.org/10.1101/cshperspect.a041319

DCIS and LCIS: Are the Risk Factors for Developing In Situ Breast Cancer Different?

Jasmine Timbres , Kelly Kohut, Michele Caneppele, Maria Troy, Marjanka K. Schmidt , Rebecca Roylance and Elinor Sawyer. Cancers 2023, 15, 4397.
doi: https://doi.org/10.3390/cancers15174397

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.

Hutten, S.J., de Bruijn, R., Lutz, C., Badoux, M., Eijkman, T., Chao, X., Ciwinska, M., Sheinman, M., Messal, H., and Herencia-Ropero, A., Kristel, P., Mulder, L.,  van der Waal, R.,  Sanders, J.,  Almekinders, M.M.,  Llop-Guevara, A.,  Davies, H.R.,  van Haren, M.J.,  Martin, N.I., Behbod, F.,  Nik-Zainal, S.,  Serra, S.,  van Rheenen, J.,  Lips, E.H., Wessels, L.F.A., Grand Challenge PRECISION Consortium; Wesseling, J.,  Scheele, C.L.G. J.,  Jonkers, J. Cancer Cell 2023 41, 986-1002. e1009
doi: https://doi.org/10.1016/j.ccell.2023.04.002
News: https://cancergrandchallenges.org/news/unique-resource-studying-dcis-and-progression-cancer

Microcalcification crystallography as a potential marker of DCIS recurrence.

Gosling, S. B., Arnold, E. L., Davies, S. K., Cross, H., Bouybayoune, I., Calabrese, D., Nallala, J., Pinder, S. E., Fu, L., Lips, E. H., King, L., Marks, J., Hall, A., Grimm, L. J., Lynch, T., Pinto, D., Stobart, H., Hwang, E. S., Wesseling, J., Geraki, K.,  Stone, N.,  Lyburn, I.D.,  Greenwood, C., Rogers, K.D., Grand Challenge PRECISION Consortium. Scientific Reports 2023, 13(1).
doi: https://doi.org/10.1038/s41598-023-33547-8
News: https://cancergrandchallenges.org/news/microcalcification-crystallography-in-dcis

Classification performance bias between training and test sets in a limited mammography dataset.

Hou R, Lo JY, Marks JR, Hwang ES, Grimm LJ. PLoS One. 2024 Feb 7;19(2):e0282402. eCollection 2024.
doi: https://doi.org/10.1371/journal.pone.0282402

Mouse intraductal modeling of primary ductal carcinoma in situ.

Hutten SJ, Behbod F, Scheele CLGJ, Jonkers J. STAR Protoc. 2023 Aug 29;4(3):102526. Epub ahead of print. PMID: 37651235; PMCID: PMC10480770.
doi: https://doi.org/10.1016/j.xpro.2023.102526

MIND the translational gap: Preclinical models of ductal carcinoma in situ.

Hutten SJ, Jonkers J. Clin Transl Med.2023 Aug;13(8):e1376. PMID: 37620984; PMCID: PMC10449811.
doi: https://doi.org/10.1002/ctm2.1376

Prediction Models and Decision Aids for Women with Ductal Carcinoma In Situ: A Systematic Literature Review.

Schmitz RSJM, Wilthagen EA, van Duijnhoven F, van Oirsouw M, Verschuur E, Lynch T, Punglia RS, Hwang ES, Wesseling J, Schmidt MK, Bleiker EMA, Engelhardt EG, Grand Challenge Precision Consortium.
Cancers (Basel). 2022 Jul 2;14(13):3259.
doi: https://www.mdpi.com/2072-6694/14/13/3259
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Learning to distinguish progressive and non-progressive ductal carcinoma in situ.

Casasent AK, Almekinders MM, Mulder C, Bhattacharjee P, Collyar D, Thompson AM, Jonkers J, Lips EH, van Rheenen J, Hwang ES, Nik-Zainal S, Navin NE, Wesseling J; Grand Challenge PRECISION Consortium.
Nat Rev Cancer. 2022 Dec;22(12):663-678.
doi: https://doi.org/10.1038/s41568-022-00512-y

A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications

Sarah Gosling, Doriana Calabrese, Jayakrupakar Nallala, Charlene Greenwood, Sarah Pinder, Lorraine King, Jeffrey Marks, Donna Pinto, Thomas Lynch, Iain D. Lyburn, E. Shelley Hwang, Grand Challenge PRECISION Consortium, Keith Rogers and Nicholas Stone
Analyst, 2022
doi: https://doi.org/10.1039/D1AN01548F
News: https://cancergrandchallenges.org/news/do-clues-breast-cancer-progression-lie-specks-seen-mammograms

Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk.

Almekinders MM, Bismeijer T, Kumar T, Yang F, Thijssen B, van der Linden R, van Rooijen C, Vonk S, Sun B, Parra Cuentas ER, Wistuba II, Krishnamurthy S, Visser LL, Seignette IM, Hofland I, Sanders J, Broeks A, Love JK, Menegaz B, Wessels L, Thompson AM, de Visser KE, Hooijberg E, Lips E, Futreal A, Wesseling J; Grand Challenge PRECISION Consortium.
Br J Cancer. 2022 Oct;127(7):1201-1213.
doi: https://www.nature.com/articles/s41416-022-01888-2

Anomaly Detection of Calcifications in Mammography Based on 11,000 Negative Cases.

Hou R, Peng Y, Grimm LJ, Ren Y, Mazurowski M, Marks JR, King LM, Maley C, Hwang ES, Lo JY
IEEE Trans Biomed Eng. 69(5): 1639-1650.
doi: 10.1109/TBME.2021.3126281 (2022)

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

Esther H. Lips, Tapsi Kumar , Anargyros Megalios , Lindy L. Visser , Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo , Maria Roman-Escorza , Ahmed A. Ahmed , Mingchu Xu, Alexandra W. van den Belt-Dusebout , Wim Brugman, Anna K. Casasent, Karen Clements, Helen R. Davies, Liping Fu, Anita Grigoriadis , Timothy M. Hardman, Lorraine M. King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C. Maley , Jeffrey R. Marks, Brian A. Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K. Schmidt, Abeer M. Shaaban , Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal , Lodewyk F. A. Wessels, E. Shelley Hwang, Nicholas E. Navin, P. Andrew Futreal, Grand Challenge PRECISION consortium*, Alastair M. Thompson, Jelle Wesseling and Elinor J. Sawyer
Nat. Gen. 9th June 2022
doi: https://www.nature.com/articles/s41588-022-01082-3
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News: https://cancergrandchallenges.org/news/step-closer-avoiding-overtreatment-people-dcis
Video: https://cancergrandchallenges.org/news/collectively-our-work-could-ultimately-save-tens-thousands-people-burden-invasive-treatment

Prediction of Upstaging in Ductal Carcinoma in Situ Based on Mammographic Radiomic Features

Rui Hou, Lars J. Grimm, MD, Maciej A. Mazurowski, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, Thomas Lynch, Marja van Oirsouw, Keith Rogers, Nicholas Stone, Matthew Wallis, Jonas Teuwen, Jelle Wesseling, E. Shelley Hwang, Joseph Y. Lo
Radiology 2022; 000:1–9
https://doi.org/10.1148/radiol.210407

Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy

Yan Hong, Darlene Limback, Hanan S Elsarraj, Haleigh Harper, Haley Haines, Hayley Hansford, Michael Ricci, Carolyn Kaufman, Emily Wedlock, Mingchu Xu, Jianhua Zhang, Lisa May, Therese Cusick, Marc Inciardi, Mark Redick, Jason Gatewood, Onalisa Winblad, Allison Aripoli, Ashley Huppe, Christa Balanoff, Jamie L Wagner, Amanda L Amin, Kelsey E Larson, Lawrence Ricci, Ossama Tawfik, Hana Razek, Ruby O Meierotto, Rashna Madan, Andrew K Godwin, Jeffrey Thompson, Susan G Hilsenbeck, Andy Futreal, Alastair Thompson, E Shelley Hwang, Fang Fan, Fariba Behbod, Grand Challenge PRECISION Consortium
J Pathol 2022 Feb; 256(2):186-201.
doi: https://doi.org/10.1002/path.5820
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Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast

Maartje van Seijen, Esther H. Lips , Liping Fu, Daniele Giardiello, Frederieke van Duijnhoven, Linda de Munck , Lotte E. Elshof, Alastair Thompson, Elinor Sawyer , Marc D. Ryser, E. Shelley Hwang, Marjanka K. Schmidt, Paula H. M. Elkhuizen, Grand Challenge PRECISION Consortium, Jelle Wesseling and Michael Schaapveld
Br J Cancer (2021); Aug 18
doi: https://doi.org/10.1038/s41416-021-01496-6
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Preferences of Treatment Strategies among Women with Low-Risk DCIS and Oncologists.

Byng D, Retèl VP, Engelhardt EG, Groothuis-Oudshoorn CGM, van Til JA, Schmitz RSJM, van Duijnhoven F, Wesseling J, Bleiker E, van Harten WH, On Behalf Of The Grand Challenge Precision Consortium. Cancers. 2021 Aug 6;13(16):3962. PMID: 34439126; PMCID: PMC8394332.
doi: https://doi.org/10.3390/cancers13163962

Treating (low-risk) DCIS patients: What can we learn from real-world cancer registry evidence?

Byng D, Retèl VP, Schaapveld M, Wesseling J, van Harten WH; Grand Challenge PRECISION consortium.
Breast Cancer Res Treat. 2021 May;187(1):187-196.
doi: https://doi.org/10.1007/s10549-020-06042-1
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Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ

Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser , Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi , Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg , Wilbert Zwart, Esther H. Lips , Grand Challenge PRECISION Consortium*, Christine Desmedt and Jelle Wesseling
npj Breast Cancer (2021) 7:31, March 22
doi: https://doi.org/10.1038/s41523-021-00232-w
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News: Could the size of fat cells around DCIS breast lesions predict risk of future invasive cancer? | Cancer Grand Challenges
News: How fat cells could help predict breast cancer | Netherlands Cancer Institute (nki.nl)
Blog: Predicting future breast cancer with precision – Cancer Research UK – Science blog

Variability in grading of ductal carcinoma in situ among an international group of pathologists

Maartje van Seijen, Katarzyna Józ´ wiak, Sarah E Pinder, Allison Hall, Savitri Krishnamurthy, Jeremy SJ Thomas, Laura C Collins, Jonathan Bijron, Joost Bart, Danielle Cohen, Wen Ng, Ihssane Bouybayoune, Hilary Stobart, Jan Hudecek, Michael Schaapveld, Alastair Thompson, Esther H Lips, and Jelle Wesseling * on behalf of the Grand Challenge PRECISION consortium.
J Pathol Clin Res 2021 Feb 23
doi: 10.1002/cjp2.201 (doi.org)
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Contralateral breast cancer risk in patients with ductal carcinoma in situ and invasive breast cancer

Daniele Giardiello, Iris Kramer, Maartje J. Hooning, Michael Hauptmann, Esther H. Lips, Elinor Sawyer, Alastair M. Thompson, Linda de Munck, Sabine Siesling, Jelle Wesseling, Ewout W. Steyerberg and Marjanka K. Schmidt
npj Breast Cancer 6, 60 (2020).
doi: https://doi.org/10.1038/s41523-020-00202-8
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Oncologieuptodate: Click Here

Prognostic value of histopathological DCIS features in a large scale international interrater reliability study

EmmaJ.Groen, Jan Hudecek, Lennart Mulder, Maartje van Seijen, Mathilde M.Almekinders, Stoyan Alexov, Anikó Kovács, Ales Ryska, Zsuzsanna Varga, Francisco Javier Andreu Navarro, Simonetta Bianchi, Willem Vreuls, Eva Balslev, Max V.Boot, Janina Kulka, Ewa Chmielik, Ellis Barbé, Mathilda J.de Rooij, Winand Vos, Andrea Farkas, Natalja E.Leeuwis Fedorovich, Peter Regitnig, Pieter J.Westenend, Loes F.S.Kooreman, Cecily Quinn, Giuseppe Floris, Gábor Cserni, Paul J.van Diest, EstherH.Lips, Michael Schaapveld, Jelle Wesseling on behalf of Grand Challenge PRECISION consortium
Breast Cancer Research and Treatment
doi: https://doi.org/10.1007/s10549-020-05816-x
Published online 30th July 2020

PRECISION Newsletter Volume 2, Issue 1, July 2020

https://www.dcisprecision.org/wp-content/uploads/2020/08/DCIS-Nieuwsbrief-Final_140820.pdf

The impact of patient characteristics and lifestyle factors on the risk of an ipsilateral event after a primary DCIS: A systematic review

Sena Alaeikhanehshir, Ellen G. Engelhardt, Frederieke H. van Duijnhoven, Maartje van Seijen, Patrick A. Bhairosing, Donna Pinto, Deborah Collyar, Elinor Sawyer, Shelley E. Hwang, Alastair M. Thompson, Jelle Wesseling, Esther H. Lips, Marjanka K. Schmidt on behalf of PRECISION
Breast 2020 Apr; 50: 95–103.
doi: 10.1016/j.breast.2020.02.006
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Calcification Microstructure Reflects Breast Tissue Microenvironment

Sarah Gosling, Robert Scott, Charlene Greenwood, Pascaline Bouzy, Jayakrupakar Nallala, Iain D. Lyburn, Nicholas Stone, Keith Rogers
Journal of Mammary Gland Biology and Neoplasia volume 24, pages333–342(2019)
doi: https://doi.org/10.1007/s10911-019-09441-3
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Ductal carcinoma in situ: to treat or not to treat, that is the question

Maartje van Seijen, Esther H. Lips, Alastair M. Thompson, Serena Nik-Zainal, Andrew Futreal, E. Shelley Hwang, Ellen Verschuur, Joanna Lane, Jos Jonkers, Daniel W. Rea and Jelle Wesseling on behalf of the PRECISION team
British Journal of Cancer volume 121, pages285–292(2019)
doi: https://doi.org/10.1038/s41416-019-0478-6

PRECISION Newsletter Volume 1, Issue 1, June 2019
https://www.dcisprecision.org/wp-content/uploads/2019/08/Final-Newsletter_11th-June-2019.pdf

Prediction of Upstaged Ductal Carcinoma in situ Using Forced Labeling and Domain Adaptation 

Rui Hou, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E. Shelley Hwang, and Joseph Y. Lo
IEEE Transactions on Biomedical Engineering (Early Access)
doi: 10.1109/TBME.2019.2940195

Predictors of an Invasive Breast Cancer Recurrence after DCIS: A Systematic Review and Meta-analyses 

Lindy L. Visser, Emma J. Groen, Flora E. van Leeuwen, Esther H. Lips, Marjanka K. Schmidt, and Jelle Wesseling
Cancer Epidemiology, Biomarkers and Prevention
doi: 1055-9965.EPI-18-0976