WORKPACKAGE 4

The role of imaging in DCIS prognosis and outcome

Hypothesis

Imaging features of both DCIS and stroma will define a cohort at increased risk for invasive progression

In WP4 we will identify a series of systematic differences in the radiographic and physicochemical characteristics of lethal, compared to non-lethal cancers.

 

We will examine the imaging characteristics, microstructure and fundamental chemistry of calcifications and adjacent tissues to develop and test a number of novel imaging biomarkers for refining DCIS prognosis and outcome, thus linking imaging findings and DCIS biology.

Workpackage 4 is responsible for the project objective to validate imaging characteristics of DCIS cohorts

Milestones

4.1 Development of x-ray, near infrared and Raman spectroscopic imaging classifiers
4.2 Digital image extraction and segmentation for development of digital mammogram classifier for poor prognosis DCIS

WP lead

Professor Shelley Hwang

Professor of Surgery

Duke University School of Medicine, Durham, NC, USA

Collaborators

Professor Joseph Lo

Duke University, Durham, North Carolina, USA

 

Professor Iain Lyburn

Cobalt Health, Cheltenham, Gloucestershire, UK

 

Professor Keith Rogers

Cranfield University, Swindon, UK

 

Professor Nik Stone

University of Exeter, Exeter, UK

 

Dr Matthew Wallis

Cambridge University Hospital, Cambridge, UK

 

Dr Kenneth Young

Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK